Be sure to read the following important information carefully. This information does not take the place of your doctor's advice. If you do not understand any portion of this information or want to know more, please ask your doctor.

Limbrel
Limbrel is a prescription medical food product for the safe clinical dietary management of the metabolic processes of osteoarthritis under a physician's supervision. Osteoarthritis is also known simply as OA.

Natural ingredients
Limbrel's two key ingredients baicalin and catechin are natural flavonoids from plants. Flavonoids in general are the healthful ingredients that give color to fruits, vegetables, cocoa, red wine and green tea. However, even if someone eats 3 or 4 pounds of fruits and vegetables everyday of the month, it is still almost impossible to get enough beneficial ingredients found in Limbrel from simple changes in eating habits. This is because the natural ingredients in Limbrel are highly purified and specially formulated for the management of osteoarthritis. Although Limbrel has been clinically shown to be safe, it is intended for people with osteoarthritis, and not for the general public. That is also why Limbrel is by prescription only, and not available over-the-counter.

Safety
The ingredients in Limbrel have Generally Recognized As Safe (GRAS) status, a strict food safety standard set by the FDA. In clinical studies, Limbrel's side effects rates were only slightly higher than placebo. Prescribed since 2004, Limbrel has been shown to be GI friendly with very few GI side effects reported. In fact, there have been very few side effects of any kind reported to date for Limbrel (total rate < 0.1%). The reported side effects have generally been mild and infrequent including some nausea and diarrhea, occasional heartburn, skin rash, joint pain and, rarely, joint swelling.

Effectiveness
In both clinical studies and in-market prescription usage under a physician's care, Limbrel has consistently demonstrated significant improvement in validated joint discomfort, stiffness and mobility measures of osteoarthritis through safe, daily dietary management. Limbrel is uniquely effective because Limbrel works with the body to manage osteoarthritis by restoring our bodies' metabolic balance, especially those responsible for inflammation. This approach is in sharp contrast to blocking or shutting down one or two specific enzyme functions to merely mask symptoms short term.

Usage
Recommended use is one (1) capsule (250 mg or 500 mg) every 12 hours, taken with or without food. The use may be increased to two or more capsules every 12 hours, as directed by a physician. Limbrel may be used while taking acetaminophen.

Packaging
Limbrel is available in 250 mg and 500 mg capsules. One bottle contains 60 capsules (a one-month supply at the recommended use).

Precautions and Contraindications
Do not take Limbrel if you are allergic or hypersensitive to fruits, vegetables, Brazilian nuts, cocoa, red wine and tea, Limbrel is not recommended for pregnant or lactating women, pediatric patients, or patients with an active bleeding gastrointestinal ulcer, because it has not been tested in these specific patient types.

For long term use, Limbrel should not be taken together with NSAIDs such as naproxen, ibuprofen, aspirin (except baby aspirin), or with any selective COX-2 inhibitors. NSAIDs and selective COX-2 inhibitors will destroy Limbrel's "balancing" effect.

Limbrel does not contain fructose, glucose, sucrose, lactose, gluten or flavors. Limbrel does not contain any parts or ingredients of nuts, soy, corn, wheat, sugar, or any fruits and vegetables.

If you experience any discomfort while taking Limbrel, inform your doctor immediately.