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Limbrel is the first prescription medical food (MF) product specially formulated for the clinical dietary
management of the metabolic processes of osteoarthritis. Originally, osteoarthritis was thought of as a
degenerative disease triggered by a trauma or injury to a joint and associated with aging. New insights,
however, have shown that after the initial damage, osteoarthritis progresses due to an excess of arachidonic
acid (AA) metabolism and oxidative activities, which increase inflammation in the joint, in turn causing
cartilage degradation.
The flavonoids in Limbrel restore the proper metabolic balance of inflammatory metabolites at the cellular
level on cyclooxygenase (COX) pathways, composed of the COX-1 and COX-2 enzymes, thereby effectively managing
osteoarthritis while minimizing common side effects. In addition, Limbrel metabolically down-regulates
inflammatory metabolite production in the LOX pathway composed of 5-LOX. Limbrel also promotes a strong antioxidant
activity in the body that limits the metabolic oxidation of AA to metabolites which directly degrade cartilage.
Limbrel’s broad-based management of the metabolic aspects of osteoarthritis allows for a high level of
safety and effectiveness for this disease state.
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